自身疣体包埋联合卡介菌多糖核酸注射液治疗扁平疣的疗效观察

Efficacy Observation of Self-verruca Embedding Combined with Bacillus Calmette Guerin-polysaccharide Nucleic Acid Injection in the Treatment of Verruca Planae

目的:观察自身疣体包埋联合卡介菌多糖核酸注射液治疗扁平疣的疗效和安全性。方法:将92例扁平疣患者随机均分为两组。试验组患者采用自身疣体包埋+卡介菌多糖核酸注射液1ml,肌肉注射+0.025%维A酸软膏,外用治疗;对照组患者不作自身疣体包埋,其他治疗同试验组。两组患者均随访3个月,比较两组患者临床疗效及安全性。结果:试验组患者总有效率为82.6%,优于对照组(51.1%),两组比较差异有统计学意义(P<0.05)。两组患者均未见严重不良反应发生。结论:自身疣体包埋联合卡介菌多糖核酸注射液治疗扁平疣疗效及安全性较好。

OBJECTIVE： To observe the clinical efficacies of self-verruca embedding combined with Bacillus calmette guerin- polysaccharide nucleic acid （BCG-PSN） injection in the treatment of verruca planae. METHODS： 92 patients with verruca planae Were randomized into two groups. 46 patients in trial group received self-verruca embedding, BCG-PSN injection and 0.025% Tretinoin cream for external use, while 46 patients in control group received same treatment except verruca embedding. And they were followed up for 3 months. Therapeutic efficacies were compared between 2 groups. RESULTS： The total efficacy of trail group was 82.6%, and control group was 51.1%. There was significant differences between 2 groups （P〈0.05）. There was no significant serious ADR found in both groups. CONCLUSION： The self-verruca embedding combined with BCG-PSN injection is effective in the treatment of verruca planae.