我院克林霉素注射剂致不良反应/事件的调查分析

Investigation and Analysis of ADR/ADE Induced by Clindamycin Injection in Our Hospital

目的:了解克林霉素注射剂致不良反应/事件(ADR/ADE)的发生规律、特点及影响因素,促进临床合理用药。方法:回顾荆门市第一人民医院2012年1-6月使用克林霉素注射剂的病例688例,对发生ADR/ADE患者性别、用药时间、联合用药、使用剂量以及ADR/ADE的具体表现等方面进行分析。结果:688例患者ADR/ADE总发生率为9.7%,男、女性发生率无显著性差异;用药时间越长、联合用药越多、使用剂量越大,ADR/ADE发生率越高;消化系统、神经系统ADR/ADE发生率较高。结论:克林霉素注射剂致ADR/ADE虽然不可预知,但只要严格按说明书使用,就可以有效减少药害事件的发生。

OBJECTIVE： To investigate the regularity, characteristics and influential factors of ADR/ADE induced by Clindamycin injection, and to promote rational drug use in the clinic. METHODS： 688 cases of Clindamycin injection in our hospital from Jan. to Jun. in 2012 were analyzed retrospectively in terms of gender, medication duration, drug combination, dosage and manifestation of ADR/ADE. RESULTS： Among 688 cases, the incidence of ADR/ADE was 9.7%, and there was no significant dif- ference on gender. It was high more and more if it was enough about the time of drug use, the variety of drug combination or overdose. The incidence of ADR/ADE was high relatively in digestive system and nervous system. CONCLUSION： ADR/ADE induced by clindamycin infection is unpredictable. To strictly use Clindamycin injection according to package inserts, ADR/ADE can be reduced effectively.