摘要
目的探讨精神分裂症患者血清蛋白和相关酶改变及其与代谢综合征的关系。方法503名住院精神分裂症患者和60名健康自愿者接受调查,收集人口学资料和病史资料,检测血清蛋白质和酶水平,按国际糖尿病联盟标准诊断代谢综合征。结果精神分裂症患者血清蛋白水平[总蛋白(71.14±6.13)g/L、白蛋白(44.56±4.24)g/L、球蛋白(26.35±5.04)g/L、载脂蛋白A(10.97±0.27)g/L和载脂蛋白B(0.69±0.25)g/L低于对照组(79.96±6.10)g/L、(49.44±5.63)g/L、(30.52±4.00)g/L、(10.97±0.27)g/L和(0.69±0.25)g/L],尿素氮(4.36±1.36)mmol/L低于对照组(5.22±1.31)mmol/L,C一反应蛋白(3.17±6.58)mg/L高于对照组(1.35±1.83)mg/L,差异均具有统计学意义(P〈0.01);丙氨酸氨基转移酶(24.28±32.76)IU/L、a—L岩藻糖苷酶(17.49±4.83)U/L、腺苷脱氢酶(17.81±5.67)U/L和肌酸激酶同工酶(10.50±4.92)IU/L高于对照组(18.12±9.77)IU/L、(15.98±3.58)IU/L、(11.75±5.48)IU/L、和(9.12±3.62)IU/L,AST同工酶(5.97±4.97)U/L低于对照组(7.05±6.72)U/L,差异均具有统计学意义(P〈0.01);精神分裂症伴代谢综合征患者丙氨酸氨基转移酶、碱性磷酸酶、γ-谷氨酰转移酶、a—L岩藻糖苷酶、AST同工酶和胱抑素C高于非代谢综合征患者,差异具有统计学意义(P〈0.05)。结论精神分裂症患者存在显著的蛋白质和酶代谢异常,许多酶代谢异常与代谢综合征显著关联。
Objective To investigate changes of serum proteins and related enzymes in patients with schizophrenia and its relationship to metabolic syndrome. Methods Five hundred and three inpatients with schizophrenia and 60 healthy volunteer were selected in this study. The demographic information and medical history data of them were recorded and levels of serum proteins and enzymes were measured, and the metabolic syndrome (MS) was diagnosed according to IDF criteria. Results Serum protein contents of schizophrenic patients (total protein ( 71.14± 6.13 ) g/L, albumin (44.56 ±4.24 ) g/L, globulin ( 26.35 ±5.04 ) g/L, apoprotein A ( 10.97 -+ 0.27 ) g/L, and apoprotein B ( 0.69 ±0.25 ) g/L) were significantly lower than control group ( 79.96 ±6.10 ) g/L, (49.44 ±5.63)g/L,(30.52 ±4.00)g/L, (10.97 ±0.27)g/L,and(0. 69 ±0.25)g/L (P〈0.01). Urea nitrogen ( (4.36 ±1.36 ) mmol/L) was lower than control group ( ( 5.22 ±1.31 ) mmol/L) and C-reaction protein ( ( 3.17 ±6.58) mg/L) was higher than control group ( 1.35 ±1.83 ) (P 〈 0.01 ). Alanine aminotransferase ( ( 24.28 -+ 32.76 ) IU/L) , a-L Fueosidase ( ( 17.49 + 4.83 ) U/L) , adenosine dehydrogenase ( ( 17.81 ±5.67 ) U/L), and creatine kinase isoenzyme( ( 10.50 ± 4.92) IU/L) were higher than control group ( 18.12 ±9.77 ) IU/L, ( 15.98 ±3.58 ) U/L, ( 11.75 ±5.48) U/L,and (9.12 ± 3.62) IU/L, P〈0.01 ) ,but AST isoenzyme ( (5.97 ±4.97) U/L) was lower than control group ( ( 7.05 ± 6.72 ) U/L). Alanine Aminotransferase, alkaline phosphatase, γ-gluta, myl transpeptidase, and a-L Fucosidase, AST isoenzyme and cystatin-c of schizophrenic patients with MS were significantly higher than non-MS patients (P 〈 0.05 ). Conclusion There are significant metabolic disorders of proteins and enzymes in patients with schizophrenia, and abnormal changes of many enzymes are significantly associated with metabolic syndrome.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2013年第3期199-201,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
江苏省卫生厅资助项目(H201043)
关键词
精神分裂症
代谢综合征
蛋白质
酶
Schizophrenia
Metabolic syndrome
Proteins
Enzymes