乳腺癌易感性及化疗敏感性与醌氧化还原酶1基因多态性的关系

Relationship between genetic polymorphisms of quinone oxidoreductase 1 and susceptibility and che- nosensitivity of breast cancer

目的探讨醌氧化还原酶1（NQ01）基因rsl800566多态性与乳腺癌易感性及化疗敏感性的关系。方法乳腺癌患者162名，健康对照者190例，乳腺癌患者分别接受多西紫杉醇＋环磷酰胺（TC）方案和表阿霉素＋5-氟尿嘧啶＋环磷酰胺（FEC）方案化疗，采用TaqMan—MGB探针终点分型法检测NQ01rsl800566位点的多态性分布，并进行统计学分析。结果NQ01rsl800566位点C携带患者的危险度较对照组降低[P〈0．05，比值比（OR）=0．60，95％可信区间（CI）=0．37-0．97]。NQ01m1800566位点的rITr基因型是乳腺癌高危基因型（P〈0．05）。NQOlrsl800566位点C等位基因携带患者的化疗有效率为64．9％，显著高于TT基因型患者（P〈0．05）。TC方案化疗患者组中，NQOlrsl800566位点CT基因型患者的化疗有效率为71．0％，显著高于TT基因型（P〈0．05），但在FEC方案化疗组中差异无统计学意义（P〉0．05）。结论NQO!rsl800566的基因多态性可能与乳腺癌的发生发展有一定的关系。

Objective To expolre the relationshio between genetic polymorphisms of quinone oxidoreductase 1 (NQO1) and susceptibility and chenosensitivity of breast cancer.Methods Totally 162 breast cancer patients and 190 non-cancer female controls were selected.The breast cancer patients were treated with TC and FEC chemotherapy.The genotypes were detected by using TaqMan-MGB probe-based real time quantitive polymerase chain reaction technology method.Results The risk of breast cancer was decreased in NQO1rs1800566 C genetic carrier [odds ratio (OR) =0.60,95％ confidence interval (CI) =0.37-0.97],compared with the controls.NQO1rs1800566 TT was the high risk genotype.The RR of C genetic carrier in NQO1rs1800566 cases was64.9％,which was significantly higher than that of the TT genotype.Among the cased administrated with TC regimens,the RR of CT genotype in NQO1rs1800566 cases was 71.0％,which was singificantly higher than that of the TT genotype.Conclusion The results indicated that the polymorphisms in NQO1 genes,which might be associated with breast cancer risk of Chinese women.