2Jiang JK, Kamran G, Francesca D, et al. Examining the chirality, conformation and selective kinase inhibition of 3- ((3R,4R) -4-methyl-3- (methyl (7H-pyrrolo [2,3- d] pyrimidin-4-yl) amino) piperidin-1-yl) -3-oxopropanenitrile (CP-690,550) [J]. JMed Chem, 2008, 51 (24) : 8012-8018.
3Dolgin E. Companies hope for kinase inhibitor JAKpot [J]. Nat Rev Drug Discovery, 2011, 10(10):717-718.
4Ruggeri SG, Hawkins JM, Makowski TM, et al. Pyrrolo [2,3- d]pyrimidine derivatives; their intermediates and synthesis: WO, 2007 012953 [P]. 2007-02-01.
5Mark EF,Todd AB, William HB, et al. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection [J]. J Med Chem, 2010, 53 (24): 8468-8484.
6David HBR, Stefan A, Cai WL, et al. Development of a scaleable route for the production of cis-N-benzyl-3- methylamino-4-methylpiperidine [J]. Org Process Res Dev, 2003, 7(1): 115-120.
7Cai WL, Colony JL, Frost H, et al. Investigation of practical routes for the kilogram-scale production of cis-3- methylamino-4-methylpiperidines [J]. Org Process Res Dev, 2005, 9(1): 51-56.
