纳米喷雾干燥技术在药物研究中的应用进展

Advance of Nano Spray Drying in Pharmaceutical Applications

纳米喷雾干燥技术是通过一步法直接制备粒度分布窄且平均粒径分布在纳米级颗粒的一项新技术。本法制备过程温和,能较好地保持药物的结构和活性,适于制备热敏性生物活性分子及难溶性药物的纳米粒。本文阐述了纳米喷雾干燥技术的原理、工艺参数及近年来在药物研究中的应用。

Nano spray drying is a novel one-step granulation technology for the preparation of nanoparticles with narrow distribution. The biologically active molecule can maintain its structure and activity because of the mild preparation process. So this technology is suitable for the preparation of thermosensitive and sparingly soluble drugs. The principle, process parameters and the pharmaceutical applications in recent years of the nano spray drying technology are reviewed in this paper.