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安普那韦合成路线图解 被引量:2

Graphical Synthetic Routes of Amprenavir
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摘要 安普那韦(amprenavir,1),化学名为(3S)-四氢.3.呋喃.N-[(1S,2R).3-(4.氨基一[N-异丁基苯磺酰胺基).1.苯基-2.羟基丙基]氨基甲酸酯,是由英国GlaxoSmithKline公司开发的抗逆转录病毒蛋白酶抑制剂,1999年5月在美国和日本上市,现已在24个国家或地区上市。
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2013年第4期408-410,共3页 Chinese Journal of Pharmaceuticals
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参考文献11

  • 1Becker S, Thornton L. Fosamprenavir: advancing HIV protease inhibitor treatment options [J]. Expert Opinion on Pharmacotherapy, 2004, 5 (9): 1995-2005.
  • 2Ghosh AK, Thompson WJ, Holloway MK, et al. Potent HIV protease inhibitors: the development of tetrahydrofuranylgly cines as novel P2-1igands and pyrazine amides as P3-1igands [J]. JMed Chem, 1993, 36 (16) : 2300-2310.
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二级参考文献12

  • 1雷厉军,何煦昌.HIV-1蛋白酶抑制剂前药的研究进展[J].药学进展,2005,29(7):295-301. 被引量:4
  • 2吴问根,王尔华.HIV逆转录酶抑制剂研究进展[J].药学进展,1996,20(1):11-16. 被引量:14
  • 3Beeker S, Thornton L. Fosamprenavir: advancing HIV protease inhibitor treatment options[J]. Expert Opin Pharmacother, 2004, 5(9): 1995-2005.
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  • 5Corey E J, Zhang nitroaldol reactions Fu-yao. Reand sifaceselective catalyzed by a rigid chiral quaternary ammonium salt: A highly stereoselective synthesis of the HIV protease inhibitor amprenavir. angew[J]. Chem Int Ed, 1999. 13/14(38): 1931- 1934.
  • 6David D, John S, Stuart M. et al. Process for the synthesis of HIV protease inhibitors[P]. WO: 99/ 48885,1999.
  • 7Victor Ekhato, Yuan Liao, Mihaela Plesescu. Isotope labeled HEA moiety in the synthesis of labeled HIV-protease inhibitors-Part Ⅰ[J]. J Label Compd Radiopharm, 2004,47 : 821-835.
  • 8Ekhato V, Liao Y, Plesescu M. Isotope labeled HEA/HEE moiety in the synthesis of labeled HIV- protease inhibitors-Part Ⅱ[J]. J Label Compd Radiopharm, 2005.48:179-193.
  • 9李荣梅.抗HIV药物沙奎那韦的合成及结构分析[D].上海:华东理工大学硕士学位论文,2006.
  • 10Kim B Moon, Sung Jin Bae, Soon Mog So, et al. Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors [J]. Org Lett, 2001,3(15) :2349 -2351.

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