盐酸帕洛诺司琼用于预防化疗所致的恶心呕吐18例临床观察

Eighteen Cases of Preventing Chemotherapy-induced Nausea and Vomiting by Palonosetron Hydrochloride

目的:观察盐酸帕洛诺司琼用于预防化疗所致急性及延迟性呕吐的疗效及不良反应。方法:将36例接受EOF方案化疗的患者分成两组,观察组18例给予盐酸帕洛诺司琼注射液,对照组18例给予格拉司琼注射液。观察其在接受化疗后的恶心呕吐程度及不良反应。结果:接受盐酸帕洛诺司琼0.25mg第1天,格拉司琼3mg/d对急性呕吐的有效率分别为77.8%和72.2%,两者无统计学差异(P>0.05);对延迟性呕吐的有效率分别为66.7%和44.5%,两者有统计学差异(P<0.05)。不良反应为头痛及便秘。结论:通过多方位、多方向的治疗,才能更好地预防和治疗恶心呕吐,提高患者对化疗的依从性,从而获得更好的临床疗效。

Objective：To investigate the curative effect of Preventing Chemotherapy-induced acute vomiting and delayed vomiting hy Palonosetron Hydrochloride. Observe adverse event at the same time. Methods：36 patients received EOF regimen is divided into two groups, observation group, 18 patients given palonosetron hydrochloride injection, the control group, i8 patients given granise tron injection. Observation of the patient＇s nausea and vomiting and two antiemetie drugs cause adverse reactions. Results：Palono setron hydrochloride 0.25rag given the first day and granisetron 3mg given once a day for acute vomiting rates were 77.8% and 72. 2% respectively, no significant difference （P〉0.05）; on delayed vomiting rate was 66.7%and 44.5%,there is significant differ ence between the two （P〈0.05）. Conclusion ： Two drugs side effects are headache and constipation.