牛黄解毒片不良反应文献分析

Literary analysis of the adverse reactions of Niuhuang-Jiedu pill

目的总结和讨论牛黄解毒片的不良反应情况。方法以牛黄解毒片为检索词，检索1970～2012年维普中国科技期刊全文数据库与万方数据库获取有关牛黄解毒片不良反应的报告病例，记录患者年龄、性别、过敏史、用药剂量、服药时程、不良反应类型等相关数据，并进行分析。结果共检索到68篇文献，发生ADR者77例。其中，过敏反应47例（61．0％）；休克13例中死亡1例：其次为砷中毒、消化系统、泌尿系统，分别占14．3％、11．7％、6．5％。结论牛黄解毒片的不良反应不容忽视，临床应用时应注意过敏史、用药剂量、用药时程等，预防不良反应的发生。

Objective To Summariz and discuss the adverse reactions of Niuhuang-Jiedu pill （NJP） in the treatment. Methods Retrieved ADR report literatures through Chinese Medical Journal Database （CMJD） and WANFANG DATA from 1970 to 2012 with NJP as the key words, got and analyzed datas including patient age, gender, dosage, medication time and ADR type. Results Sixty-eight literatures with seventy-seven ADR report cases were retrieved. Adverse action induced by NIP was mainly allergic response, including arseniasis, gastrointestinal, uropoiesis reactions. Among 77 ADR cases, 47 cases were considered as allergic response, 61.0% of the total, one death and thirteen shock cases were included. The number of arseniasis, gastrointestinal, uropoiesis reactions cases were respectively 14.3%, 11.7%, 6.5% of the total. Conclusion The ADR of NJP should not be ignored. Allergy history, dosage and medication time should be pay more attention to to prevent the ADR of NJP to the fullest extemt.