他汀类药物对急性冠脉综合征患者房颤的影响

Influence of statins on atrial fibrillation in patients with acute coronary syndrome

目的探讨他汀类药物对急性冠脉综合征(ACS)患者房颤的影响。方法选择2010年1月至2011年6月心脏重症监护室(CCU)的ACS患者234例为研究对象,分为非他汀类组和他汀类组。CCU期间全程心电监护,比较两组房颤的发生率,并探讨房颤的预测因子。结果非他汀类组房颤发生率为17.13%,他汀类组为5.66%,房颤发生率明显降低,差异有统计学意义(χ2=4.34,P<0.05)。左房直径、他汀类药物用药史、年龄、高血压、既往房颤史、血管紧张素Ⅱ受体拮抗剂(ARB)或血管紧张素转换酶抑制剂(ACEI)用药史可作为房颤独立的预测因子。结论他汀类药物治疗ACS患者能降低其房颤的发生率。

Objective To disscuss the influence of statins on atrial fibrillation in patients with acute coronary syndrome. Methods A total of 234 patients with acute coronary syndrome who were admitted in CCU were assigned into without statins group and statins group. The continuous ECG monitoring was arranged for the two groups. The incidence rate of atri- al fibrillation were compared. Results The incidence rate of atrial fibrillation in group without statins was 17.13% while the statins group was 5.66%. The difference of incidence rate of atrial fibrillation between two groups was statistically sig- nificant （X2=4.34,P〈O.05）. Left atrial diameter, use of statin, age, hypertension, previous AF and use of ARB or ACEI were atrial fibrillation independent predict factors. Conclusions In patients with acute coronary syndrome, statin therapy can reduce the incidence rate of atrial fibrillation.