32例急性早幼粒细胞性白血病疗效分析

Clinical Analysis of Therapeutic Effects in 32 Cases with Acute Promyelocytic Leukemia

目的:观察全反式维甲酸(ATRA)、亚砷酸(AS2O3)联合化疗方案治疗成人急性早幼粒细胞性白血病(APL)的临床疗效。方法:回顾性分析32例初治APL患者临床资料,比较ATRA单药诱导治疗组与ATRA联合AS2O3诱导治疗组的缓解率、早期死亡率及并发症情况。结果:联合诱导组与单诱导组比较,CR率差异无统计学意义(P>0.05),但缓解时间明显短于单诱导组(P<0.05)。结论:联合用药诱导初发APL缓解的疗效优于单用ATRA组,是临床值得推广的方案。

Objective： To observe the clinical efficacy of the chemotherapy regimen with all -trans retinoic acid （ATRA） combined with arsenic trioxide in adult patients with acute promyelocytic leukemia. Methods： The clinical data of 32 newly diag- nosed patients with acute promyelocytic leukemia were retrospectively analyzed, and the remission rate, early mortality rate, and complications were compared between the cases treated with ATRA （ ATRA group） and the patients treated with ATRA combined with srsenic trioxide （combination group）. Results： The difference in remission rate was not significant between two groups, but the time required for complete remission in combination group was significantly shorter than in ATRA group. Conclusion： For the patients with acute promyelocytic leukemia, the clinical efficacy of ATRA combined with arsenic trioxide is better than that of AT- RA. ATRA combined with arsenic trioxide chemotherapy regimen is worthy of promotion.