丙种球蛋白佐治对重症肺炎支原体肺炎患儿血清细胞因子的影响

Influence of Immunoglobulin Adjunctive Therapy on Serum Cytokines in Treatment of Severe Mycoplasma Pneumonia in Children

目的分析静脉注射人免疫球蛋白(IVIG)佐治儿童重症肺炎支原体肺炎(MPP)的疗效和对患儿血清细胞因子的影响。方法选择医院收治的重症MPP患儿126例,随机分为观察组和对照组各63例。两组患儿均予对症支持治疗及阿奇霉素、红霉素序贯治疗,疗程2周。观察组在对照组基础上加用IVIG 400 mg/(kg.d),连用3 d。结果观察组患儿显效37例,有效23例,无效3例;对照组患儿显效19例,有效26例,无效18例。治疗后两组患儿的细胞因子水平比较,差异有统计学意义(P<0.05)。结论IVIG佐治重症MPP患儿的疗效确切,建议临床推广。

Objective To analyze the effect of intravenous immunoglobulin（IVIG） in the treatment of severe children mycoplasma pneu- moniae pneumonia（MPP） and its influence on serum cytokines. Methods A hundred and twenty- six cases of severe children MPP treated in our hospitals were selected and randomly divided into the observation group and control group,63 cases in each group. The two groups were given symptomatic supportive therapy and azithromycin, erythromycin sequential treatment, for 2 weeks. On the basis of the control group treatment,the observation group was added IVIG 400 mg/（kg ~ d）,for continuous 3 d The. Results In observation group,37 cases were excellent,23 cases were effective and 3 cases were ineffective. In the control group, 19 cases were excellent,26 cases were effective and 18 cases were ineffective. The cytokines levels after treatment showed statistical difference between the two groups （P 〈 0.05）. Conclusion IVIG is exactly effective in the adjunctive treatment of severe children MPP patients and recom- mended to be popularized in clinic