抑酸与不同抗菌药治疗幽门螺杆菌相关性消化性溃疡的对照研究

Control study the therapy effect of different antibiotic and omeprazole on helicobacter pylori associated digestive ulcer

目的:评价洛赛克、羟氨苄青霉素二联疗法对幽门螺杆菌(HP)相关性消化性溃疡的疗效。方法:将83例HP阳性的胃和十二脂肠溃疡患者按就诊顺序分为A、B两组。A组43例,每次口服洛赛克20mg,1天1次,21天,羟氨苄青霉素500mg,1天3次,14天。B组40例,在A组服药的基础上再给甲硝唑400mg,1天3次,14天。结果:两组溃疡愈合率分别为93.0%、95.0%,HP消除率分别为81.4%、85.0%。结论:两组溃疡治愈率和HP消除率差异无显著性(P>0.05),B组副作用明显高于A组(P<0.05)。

Objictive: To evaluate the double therapy effect of omeprazole and amoxicillin on the helicobacter pylori associated digestive ulcer.Method:83 HP positive patients with duodenal and gastric ulcer were divided into two groups at random.The group A(43 cases)received 21 days treatment with omeprazole,quaque in die,amoxicillin(500mg),three times a day,14 days treatment.The group B(40 cases)received 14 days treatment based on the therapy of the group A,metronidazole 400mg,three times a day.Result:The duodenal and gastric ulcer healing rates of two groups were 93.0% and 95.0%.The eradication rates of them were 81.4% and 85.0%.Conclusion:There was no significant difference between the two groups in digestive ulcer healing rate and the HP eradication( P <0.05).The side effect of the group B was significant higher than the group A( P <0.05). [