生物丁醇代谢工程的研究进展

Metabolic engineering for biobutanol production:a review

丁醇作为一种重要的大宗化学品具有广泛的用途,同时又是一种潜在的生物燃料。随着能源与环境危机的日益加重,利用可再生原料通过微生物法生产丁醇受到全世界的普遍关注。代谢工程为定向改造微生物生产丁醇提供了有力的工具。通过改造经典的丙酮丁醇发酵和定向改造模式微生物生产丁醇是生物丁醇研究的两个重要方向。笔者从代谢工程改造的角度评述近5年来生物丁醇研究的进展,同时讨论了生物丁醇研究中需要着力解决的问题。

Butanol is an important bulk chemical with wide application. Butanol was considered as a new biofuel alternative. Due to the energy and environment crisis, bio-based butanol production from sustainable biomass has been paid attention worldwide. Metabolic engineering as an efficient tool has been used widely for biobutanol production with different microorganisms. Metabolic engineering classic acetone-butanol-ethanol（ABE） fermentation was a significant direction for better butanol production. The rational design butanol producing pathway in model bacteria was another choice for butanol production. In this review, the progresses on metabolic engineering of butanol production in recent five years were summarized, the problems in butanol production to meet the demands of industrial production were also discussed.