铜绿假单胞菌亚胺培南耐药株的临床感染及其诱因分析

DETECTION OF IMIPENEM-RESISTANT PSEUDOMONAS AERUGINOSA AND RISK FACTORS

目的 :探讨亚胺培南耐药的铜绿假单胞菌临床感染情况及其危险因素。方法 :对各科送检的痰、尿、分泌物等标本进行培养并采用肉汤稀释法对亚胺培南等 8种抗生素进行最小抑菌浓度分析。结果 :分离的 36 0 %铜绿假单胞菌菌株呈现亚胺培南耐药 ,以ICU病房、高干病房的患者为主 ,病情较重 ,31 4%的患者使用过罗氏芬 ,2 0 0 %的患者用过泰能。结论 :随着抗生素的大量使用 ,越来越多的铜绿假单胞菌对亚胺培南耐药 ,多发生于危重、体弱的患者 ,耐药的发生与临床其它类型的抗生素使用有关。

Objective:To explore clinical infectious status of imipenem-resistant Pseudomonas aeruginosa with its risk factors.Methods:Sputum,urine and pus samples from clinical departments were cultured to investigate Pseudomonas aeruginosa. Antibiotic susceptibility patterns was studied by using broth microdilution method.Results:36 0% of strains represented imipenem resistant,mainly isolated from ICU and wards for senior cardres.20 0% of patients got imipenem chemothrapy,31 4% had ceftrixone chemothrapy.Conclusion:More imipenem-resistant Pseudomonas aeruginosa appeared,mainly distributed from critical and immuno-compromised patients.Different exposures to other antimicrobial agents played an important role.