米索前列醇阴道置药预防产后出血的临床观察

Clinical Study on Reduction of Postpartum Bleeding by Intravaginal Misoprostol

目的 观察米索前列醇产后阴道置药预防产后出血的疗效。方法 选择 51 2例住院分娩者随机分为 3组 :米索前列醇组、催产素组及米索前列醇 +催产素组 (合用组 )。米索前列醇组 82例在分娩后 40min内处理完伤口后于阴道后穹窿置药米索前列醇40 0 μg ,催产素组 2 2 7例在分娩后立即肌内注射催产素 2 0U ,合用组 2 0 3例则同时应用米索前列醇和催产素 ,用药方法分别与米索前列醇组和催产素组相同。 3组均用容积法及面积法观察产后 2h内及产后 2 4h内出血量。结果 米索前列醇组与合用组的产后出血量均少于催产素组 ,差异有显著性 (P <0 .0 0 1 ) ,但米索前列醇组与合用组的产后出血量的差异无显著性 (P >0 .0 5) ,且催产素组发生产后出血 4例 ,而米索前列醇组与合用组均未发生产后出血。结论 米索前列醇加强宫缩的效果比催产素好 。

Objective [WT6BZ]To observe the effects of misoprostol placed in vagina on reduction of postpartum bleeding.Methods Five hundred and twelve inpatient parturients were divided into three groups randomly.400μg misoprostol was placed in the posterior fornix vagina after handling vulnus in 40 min postpartum in misoprostol group,20U oxytocin was injected in oxytocin group postpartumly.In combined group misoprostol and oxytocin were given according to the other groups.The postpartum bleeding in 2 hours and 24 hours was collected by volume and area method.Results The bleeding of misoprostol group as well as the combined group was less than that of oxytocin group,which difference was significant( P <0.001).But there is no significant difference between misoprostol group and combined group( P >0.05),and 4 cases of postpartum hemorrhage were occurred in the oxytocin group but the other two groups.Conclusions Misoprostol via vagina is more effective in reduction of postpartum bleeding than that of oxytocin. [WT6HZ]