亚低温对脑出血患者立体定向引流术后颅内压及神经保护的作用

The Effect of Mild Hypothermia on Intracranial Pressure and Neural Protection in Patients with Intracerebral Hemorrhage after Stereotactic Evacuation

目的研究亚低温治疗对脑出血立体定向引流术后患者颅内压(ICP)、S-100B、血糖、神经功能评分及病死率的影响。方法将入选的47例脑出血(ICH)患者均给予立体定向引流术,术后随机分组并给予常规治疗及亚低温治疗。2组患者于术后连续7d监测ICP;术后当天及第3、5、7天检测S-100B、血糖;术后当天及第2、4、12、24和48周采用欧洲卒中评分量表评估患者的神经功能恢复情况并统计病死率。结果与常规治疗组比较,亚低温组患者ICP、S-100B、血糖均显著降低,神经功能评分值提高,2组病死率(17.39%vs20.83%)差异无统计学意义。结论亚低温治疗可以降低患者ICP,促进患者神经功能恢复。

Objective To investigate the effects of mild hypothermia on the intracranial pressure （ICP）, S-100B, blood glucose, mortality and the neural scores in patients with intracerebral hemorrhage （ICH） after stereotactic evacuation. Methods The patients with ICH were randomly divided into control group （23 patients） and hypothermia group （24 patients） after operation. The treatment group accepted the mild hypothermia. In both group, the ICP was continuously measured in the first week. The S-100B and blood glucose were tested at the day of operation and 3,5 and 7- day after operation. The Neurological Deficit Scale Score was used to evaluate the neural function and mortality in patients at the day of operation and 2,4, 12,24,48-week after operation. Results Compared with the control group, the values of ICP, S-100B and blood glucose were significantly reduced, and scale score was increased in treatment group. There was no significant difference in the mortality between two groups （17.39% vs 20.83%）.Conclusion The mild hypothermia can assist to improve clinical outcome in patients with ICH after stereotactic evacuation,which is worth further clinical study.