甲状腺疾病与骨钙素

Relationship between thyropathy and bone gla protein

目的 观察甲亢、甲减患者血清骨钙素 (BGP)含量 ,探讨甲状腺功能异常与骨代谢的关系。方法 测定 4 0例甲亢患者 ,2 0例甲减患者血清 BGP及甲状腺激素含量 ,并与 30例正常对照组比较。结果 甲亢患者血清 BGP含量明显高于正常对照组 (P<0 .0 1) ,甲减患者血清 BGP含量明显低于正常对照组 (P<0 .0 1) ,BGP的含量与甲状腺激素 (FT3 、FT4 )显著正相关 ,与 s TSH显著负相关 ,与性别无明显相关。结论 甲亢患者甲状腺激素增高可使成骨细胞活性增加 ,骨转换加快 ,而甲减患者则骨形成减少 ,BGP含量可作为观察甲状腺疾病患者骨病的敏感指标。

Objective\ To assess the changes of serum bone gla protein (BGP) in patients with hyperthyroidism and hypothyroidism and study the relationship between thyroid function disturbance and bone metabolism.Methods\ Serum level of BGP and thyroid hormone were measured in 40 patients with hyperthyroidism,20 hypothyroidism and 30 normal controls. Results \ Serum levels of BGP were significantly higher in the patients with hyperthyroidism ( P<0 01) and significantly lower in the patients with hypothyroidism( P< 0 01) than in the normal sujects.Highly significant positive correlation was seen between BGP and FT 3,FT 4. and highly significant negative correlation between BGP and sTSH.Conclusion\ High bone turnover exists in hyperthyroidism,and bone formation decreases in hypothyroidism.Serum BGP can be a sensitive marker for bone metabolism disturbance in patients with thyropathy.