摘要
目的 用核仁银染强度探讨肿瘤患者外周血Th淋巴细胞rDNA转录活性与机体免疫状况的关系。方法 应用计算机图象分析系统对癌症、炎症、非肿瘤非炎性疾病患者及正常人外周血Th(CD+ 4)淋巴细胞中的核仁银染强度进行比较。结果 与炎症、非肿瘤非炎症疾病患者及正常人相比 ,癌症患者Th淋巴细胞核仁银染强度显著下降。结论 癌症患者淋巴细胞rDNA转录活性的大小可以灵敏地反映体内癌变进展程度与机体免疫状况的相互关系。提示这一结果有可能为临床诊断癌症提供一个新的、简便可行的方法。
? Objective To explore the relationship between rDNA transcriptional activity of CD + 4+helper T cell and immunity in cancer patients by the silver stain of nucleolus organizing regions (Ag NORs).Methods The Th(CD + 4) rDNA transcriptional activity was compared among patients with cancer,with infectious diseases,with non cancer or non infectious diseases by image analysis.Results the Th(CD + 4) rDNA transcriptional activity was decreased extremely in patients with cancer but increased in patients with inflammation compared with normal controls.Conclusions The anlysis of Th(CD + 4) rDNA transcriptional activity may be helpful for tumor diagnosis and differential diagnosis,which is an innovative and reliable method for cancer research. 〔
出处
《中国肿瘤临床与康复》
2000年第4期6-8,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
