马兜铃酸肾病:一个仍需重视的问题

Aristolochic Acid Nephropathy: an Issue Worth More Attention

马兜铃酸肾病(aristolochic acid nephropathy,AAN)仍然是我国常见的慢性肾间质性疾病,其病程呈进行性发展至终末期肾脏病,所以AAN是一个仍需重视的问题。本文从马兜铃酸在体内的代谢、上皮间叶细胞转分化、组学研究、免疫炎症、自噬的角度综述了近年来马兜铃酸肾病的研究进展,旨在认识AAN发病机制,为进一步寻找干预靶点提供依据。

Aristolochic acid nephropathy （AAN）, a progressive renal interstitial fibrosis frequently resulting in end stage renal disease, still remains a common chronic interstitial nephropathy in China. Therefore, great attention should be paid to AAN. This review summarized recent research progress of AAN in terms of in vivo aristolochic acid metabolism, epithelial mesenchymal transition, proteomics, immunity-inflammation, and autophagy, which will help to further understand the pathogenesis of AAN, and to search effective intervention targets.