旋毛虫对宿主免疫应答调节机制的研究进展

Research Progress on the Mechanism of Host Immune Response Regulated by Trichinella spiralis

旋毛虫病是由旋毛虫(Trichinella spiralis)引起的一种呈世界性分布的人兽共患寄生虫病,严重影响畜牧业发展和食品安全,从而威胁人类健康。旋毛虫具有逃避宿主免疫应答进而在宿主体内形成长期感染的能力。研究认为,旋毛虫改变宿主免疫状态是其逃避免疫应答的重要原因,其中细胞因子、树突状细胞和调节性T细胞在其调节宿主免疫过程中发挥着重要作用。

Trichinosis caused by Trichinella spiralis is a parasitic zoonosis with world-wide distribution, which impacts on the development of animal husbandry and food safety, and thus threatens human health. T. spiralis has the ability to evade the host immune response, which results in forming a long-term infection in the host. The previous studies indicated that a changed host immune state due to T. spiralis was an important reason for the evasion. Among the factors, cytokines, dendritic cells and regulatory T cells played an important role in the regulation of the host immune process.