摘要
本研究以人群为基础,按人口构成比及年龄分层的随机整群抽样,研究了成都市1 854名女性血清游离睾酮(FT)和总睾酮(TT)的相关关系。采用多毛及痤疮评分,分别评估与FT和TT的相关关系,作出ROC曲线。结果证明,以TT诊断成都市女性高雄激素血症的界限值为0.635ng/mL,可用于成都市女性高雄激素血症的诊断,其诊断特异度与灵敏度分别为76.3%和77.24%;FT与TT具有直线相关关系,相关系数r=0.597,决定系数r2=0.356,P<0.001;FT与痤疮评分间有较弱的正相关关系,相关系数r=0.137;FT与多毛评分间无相关关系,相关系数r=0.02,;TT与多毛评分及痤疮评分间有较弱的正相关关系,相关系数分别为r=0.069及r=0.092。由此可见,高雄激素血症的生化指标与临床表现应区别而论。
This paper is aimed to analyze the correlation between serum free testosterone (FT) and total testosterone (TT) to acquire a cutoff about using total testosterone to diagnose hyperandrogenism in Chengdu females. We inves- tigated 1854 women by cluster sampling method, detected their serum FT levels and TT levels, scored relative i- tems, analyzed the correlation and made the ROC curve to get a cutoff of TT levels. Serum FT had a linear correla- tion with serum TT (r=0. 597, r^2 =0. 356, P〈0. 001). The cutoff value was 0. 635ng/mL. The specificity and sensitivity were 76.3% and 77.24%, respectively. No correlation found between serum FT and Ferriman-Gallway Score (P=0. 392). Positive correlations were seen between serum FT and Plewig-Kligman Score (r=0. 137, P〈 0. 001), serum TT and Ferriman-Gallway Score (r=0. 069, P=0. 003) and serum TT and Plewig-Kligman Score (r = 0. 092, P〈0. 001). There is a linear correlation between serum FT and TT. We can diagnose hyperandrogenism according to the serum TT cutoff value (0. 635ng/mL). Its clinical symptoms are not paralleled with the biochemical test results.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2013年第2期355-358,共4页
Journal of Biomedical Engineering
基金
四川省卫生厅科学研究项目资助(100377
060020
090289)
关键词
游离睾酮
总睾酮
高雄激素血症
多毛
痤疮
多囊卵巢综合征
Free testosterone (FT)
Total testosterone(TT)
Hyperandrogenism
Hypertrichosis
Acne
Polycystieovarian syndrome (PCOS)