成都市女性血清游离睾酮与总睾酮相关分析

Correlation Analysis Between Serum Free Testosterone and Total Testosterone in Chengdu Females

本研究以人群为基础,按人口构成比及年龄分层的随机整群抽样,研究了成都市1 854名女性血清游离睾酮(FT)和总睾酮(TT)的相关关系。采用多毛及痤疮评分,分别评估与FT和TT的相关关系,作出ROC曲线。结果证明,以TT诊断成都市女性高雄激素血症的界限值为0.635ng/mL,可用于成都市女性高雄激素血症的诊断,其诊断特异度与灵敏度分别为76.3%和77.24%;FT与TT具有直线相关关系,相关系数r=0.597,决定系数r2=0.356,P<0.001;FT与痤疮评分间有较弱的正相关关系,相关系数r=0.137;FT与多毛评分间无相关关系,相关系数r=0.02,;TT与多毛评分及痤疮评分间有较弱的正相关关系,相关系数分别为r=0.069及r=0.092。由此可见,高雄激素血症的生化指标与临床表现应区别而论。

This paper is aimed to analyze the correlation between serum free testosterone （FT） and total testosterone （TT） to acquire a cutoff about using total testosterone to diagnose hyperandrogenism in Chengdu females. We inves- tigated 1854 women by cluster sampling method, detected their serum FT levels and TT levels, scored relative i- tems, analyzed the correlation and made the ROC curve to get a cutoff of TT levels. Serum FT had a linear correla- tion with serum TT （r=0. 597, r^2 =0. 356, P〈0. 001）. The cutoff value was 0. 635ng/mL. The specificity and sensitivity were 76.3% and 77.24%, respectively. No correlation found between serum FT and Ferriman-Gallway Score （P=0. 392）. Positive correlations were seen between serum FT and Plewig-Kligman Score （r=0. 137, P〈 0. 001）, serum TT and Ferriman-Gallway Score （r=0. 069, P=0. 003） and serum TT and Plewig-Kligman Score （r = 0. 092, P〈0. 001）. There is a linear correlation between serum FT and TT. We can diagnose hyperandrogenism according to the serum TT cutoff value （0. 635ng/mL）. Its clinical symptoms are not paralleled with the biochemical test results.