磁共振动脉自旋标记成像在阿尔茨海默病脑血流灌注的研究

Measurement of Cerebral Blood Flow Using Arterial Spin Labeling Magnetic Resonance Imaging in Patients with Alzheimer's Disease

目的:应用全脑3D伪连续动脉自旋标记(pcASL)磁共振成像技术对阿尔茨海默病(AD)患者的脑血流灌注特点进行初步研究。方法:16例AD患者(AD组)和16例年龄匹配的认知功能正常老年人(对照组)进行核磁共振形态学和ASL灌注成像检查。利用SPM8软件对获得的脑血流图像进行预处理并统计分析,比较2组的脑血流灌注差异,并探讨AD患者的脑血流特点。结果:与对照组相比,AD组内侧颞叶萎缩明显,双侧额颞顶枕血流灌注普遍减低(P<0.001),主要累及左侧额叶、右侧眶额下部、右侧海马旁回、双侧顶叶下部、右侧顶叶上部、右侧缘上回、右侧楔前叶、右侧中扣带回、左侧中央后回、右侧颞叶中部(P=0.000)。经部分容积校正后,AD组双侧颞叶及顶枕交界区脑血流灌注明显减低(P<0.001)。结论:3D pcASL通过测定脑血流可以监测AD患者脑功能变化。

Objective： To investigate cerebral blood flow （CBF） characteristics in patients with Atzheimer＇s disease by using a whole-brain 3D pseudoeontinuous arterial spin-labeling technique. Methods： Sixteen AD patients and 16 age-matched cognitively normal control subjects were studied at 3.0T MR system. CBF maps were preproeessed by SPM8 software and compared by two-sample t test between the AD and control groups. Results： Patients with AD showed lower CBF values compared with that in control group throughout the brain （P〈0.001）, most prominently in the following regions： frontal lobe （L）, inferior orbitofrontal （R）, parahippocampal （R）, inferior parietal （R and L）, anterior parietal （R）, supermarginal （R）, precunei （R）, middle cingulated （R）, postcentral （R） and middle temporal （R） （P=0.000）. Regarding partial volume effects, corrected CBF in patients with AD decreased obviously in bilateral temporal gyris and parieto-occipital border zones （P〈0.001）. Conlusion： 3D pseudo-continuous arterial spin labeling imaging technique can monitor brain function by measuring CBF changes in patients with AD.