血清触珠蛋白与动脉粥样血栓形成性脑卒中的关联研究

Association between Serum Haptoglobin and Atherothrombosis Stroke

目的:探讨血清触珠蛋白(Hp)水平与动脉粥样硬化血栓形成性脑卒中(AT)的发生风险及其严重程度的关系。方法:采用回顾性病例-对照研究,纳入AT患者80例为病例组,应用美国国立卫生研究院卒中量表(NHISS)进行神经功能缺损程度评分;于同期体检门诊人群中随机抽取年龄、性别匹配的无心、脑及周围动脉粥样硬化病史者80例为对照组。记录相关危险因素,测定血清Hp浓度;单因素及多因素分析2组Hp水平差异;进一步按Hp水平进行四分位数分层,多因素Logistic回归模型分析不同Hp水平对AT发生风险的影响。Spearman秩相关及偏相关分析检测病例组Hp水平与NIHSS评分的相关性。结果:病例组血清Hp水平显著高于对照组(P=0.003),校正相关危险因素后,差异仍有统计学意义(P=0.005);校正相关危险因素后,最高四分位Hp水平发生AT的风险是最低四分位的3.356倍(P=0.025);血清HP水平与NIHSS评分呈正相关(P=0.004);进一步偏相关分析亦有统计学意义(P=0.021)。结论:Hp是一种新型的炎性反应标志物,可用于预测AT发生风险及严重程度。

Objective： To investigate the relationship between Haptoglobin （Hp） and atherothrombosis stroke （AT）. Methods： A total of 80 patients with AT and 80 age and sex matched controls without history of stroke and relevant vascular diseases were enrolled in this retrospective case-control study. The deficiency in- tensity of neurofunction was evaluated with the American National Institutes of Health （NHISS） at admission separately. All demographic parameter and relateded risk factors of characteristic in questionnaire were collect- ed. The serum Hp level was measured by Enzyme-Linked Immunosorbent Assay （ELISA）. Univariate and multiple logistic regression models were used to explore the differences between the case group and control group. Furthermore, the 80 patients were randomly divided into four groups according to quartile of Hp level and multiple logistic regression analysis were used to test the association between the risk of AT with Hp at different levels. Correlation between Hp level and NIHSS score was carried out by Spearman rank correlation test and Partial correlation analysis. Results： The level of Hp in the case group was significantly higher com- pared with control group （P=0.003） and this result did not altered after adjustment for related risk factors （P=-0.005）. The Hp level in the upper quartile was 3.356 times higher than Hp in the lower quartile after cor- rection related risk factors （P=-0.025）. There was a positive correlation between the Hp level and NIHSS score in spearman rank correlation analysis （P=0.004） and partial correlation analysis （P=0.021）. Conclusion： Hp is a novel inflammatory indicator that could predict AT happening and its severity.