脑梗死后认知损害与神经功能恢复关系的研究

The Correlation between Cognitive Impairment after Cerebral Infarction and the Recovery of Neurological Function of Patients with Cerebral Infarction

目的:评价脑梗死后认知功能损害与神经功能恢复的相关性。方法:连续纳入脑梗死患者211例,根据蒙特利尔认知评估量表(MoCA)测评结果分为无认知损害组46例及认知损害组165例,比较2组患者入选时和随访3个月时的Barthel指数(BI)及美国国立卫生院脑卒中量表(NIHSS)评分及其改善程度;并评估MoCA分值与BI和NIHSS评分及其改善程度的相关性。结果:在入选时及随访3个月时,无认知损害组患者NIHSS评分低于且BI评分高于认知损害组患者(P<0.05),BI及NIHSS评分的改善程度均大于认知损害组(P<0.05);入选时及随访3个月时,所有患者MoCA分值与NIHSS评分呈负相关,与BI评分呈正相关,与BI及NIHSS评分的改善程度呈正相关(P<0.05)。结论:脑梗死后的认知功能损害会阻碍患者神经功能的恢复。

Objective： To assess the association between cognitive impairment and the recovery of neuro- logical function in patients with cerebral infarction. Methods： Two hundred and eleven cases of acute cerebral infarction were enrolled and divided into no cognitive impairment group and cognitive impairment group based on Mont-real Cognitive Assessment （MoCA）. Barthel Index （BI） and National Institutes of Health Stroke Scale （NIHSS） score for all participants at enrollment and 3 months after strokes were documented and analyzed. Re- suits： At enrollment and month 3, in the no-cognitive impairment group the NIHSS scores was lower and the BI scores higher than those in the cognitive impairment group （P〈0.05）. The MoCA scores was negatively cor- related with NIHSS scores and positively correlated with BI scores （P〈0.05）. Conclusion： Cognitive impairment after cerebral infarction will obstruct the recovery of neurological function.