三种方法治疗获得性早期梅毒的临床疗效分析

Clinical analysis of three methods in the treatment of acquired early syphilis

目的:观察三种方法治疗获得性早期梅毒的疗效。方法:将76例患者分为三组,分别用苄星青霉素(47例)、普鲁卡因青霉素(18例)及阿奇霉素(11例)治疗,观察其临床疗效,并随访追踪疗后1年及2年,非梅毒螺旋体抗原血清学试验(RPR/USR)阴转情况;结果:三组的治愈率分别为93.62％、88.89％、81.82％。RPR/USR1年阴转率三组分别为93.62％、88.89％、100％;2年的阴转率三组均为100％;结论:治疗获得性早期梅毒,苄星青霉素和水剂普鲁卡因青霉素一样有效,仍为治疗的首选药物,阿奇霉素作为青霉素替代治疗的药物,值得推荐。

Objective: To assess the effect of three methods in treating acquired early syphilis.Methods: 76 patients of acquired early syphilis were randomized into three groups.They were treated separately with penicillin G benzathine(47 cases),penicillin G procaine (18 cases) and Azithromycin (11 cases),Results: The cure rate of group treated with P.G.benzathine was 93.62%,with P.G.procaine was 88.89%,with Azithromycin was 81.82%.After treatment,One year late,the seronegative rate of RPR of USR in these groups were 93.62%,88.89% and 100% respectively.And two year late,these seronegative rate were 100% in all groups.Conclusion: P.G.benzathine and P.G.procaine remains the drug of choice for treatment of acquired early syphilis.They are all effectively.In penicillin-allergic patients and penicillin-fail patients,Azithromycin would be chose to treat.