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Endocrine disruptors and falling sperm counts： lessons learned or not! 被引量：2

Endocrine disruptors and falling sperm counts： lessons learned or not!
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摘要 In summary, it has become evident that multiple factors can affect sperm counts and quality. Most reports indicate that there has not been a worldwide decrease in sperm counts over the past 20 or 50 years, and the validity of the endocrine disruptor hypothesis or testicular dysgenesis syndrome with respect to sperm counts is highly questionable. In summary, it has become evident that multiple factors can affect sperm counts and quality. Most reports indicate that there has not been a worldwide decrease in sperm counts over the past 20 or 50 years, and the validity of the endocrine disruptor hypothesis or testicular dysgenesis syndrome with respect to sperm counts is highly questionable.
作者 Stephen Safe
机构地区 Department of Veterinary Physiology and Pharmacology Institute of Biosciences and Technology
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2013年第2期191-194,I0005,共5页 亚洲男性学杂志（英文版）
分类号 S828.34 [农业科学—畜牧学] X503.1 [环境科学与工程—环境工程]
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参考文献61

  • 1Safe S. Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Crit Rev Toxico11984; 13: 319-95.
  • 2Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p- dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic consi- derations which support the development of toxicequivalency factors (TEFs). Crit Rev Toxicol 1990; 21: 51-88.
  • 3Safe SH. Polychlorinated biphenyls (PCBs): environ- mental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 1994; 24: 87-149.
  • 4Poland A, Glover E, Kende AS. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p- dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 1976; 251: 4936-46. P.
  • 5oland A, Knutson JC. 2,3,7,8-tetrachlorodibenzo-p- dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxico11982; 22: 517-54.
  • 6van den Berg M, Birnbaum L, Bosveld AT, Brunstrom B, Cook Pet al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 1998; 106: 775-92.
  • 7van den Berg M, Birnbaum LS, Denison M, de Vito M, Farland Wet al. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 2006; 93: 223-41.
  • 8Romkes M, Safe S. Comparative activities of 2,3,7,8- tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus. Toxicol Appl Pharmaco11988; 92: 368-80.
  • 9Romkes M, Piskorska-Pliszczynska J, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats. Toxicol ADDI Pharmaco11987: 87: 306-14.
  • 10Krishnan V, Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. Toxicol Appl Pharmaco11993; 120: 55:51.

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Asian Journal of Andrology
2013年 第2期

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