补肝益肾法对更年期模型大鼠行为变化的调节作用

Regulatory effect of nourishing liver and kidney method on the behavior changes of climacteric rats

目的:探讨补肝益肾法对更年期模型大鼠行为变化的调节作用,以期从方药的角度探究"肝肾同源"机理。方法:以去卵巢大鼠建立更年期动物模型,观察补肝药物、益肾药物和补肝益肾药物对其体质量、子宫和阴道重量/系数及行为变化的影响。结果:补肝益肾药物可明显增加更年期模型大鼠子宫和阴道重量/系数,降低更年期模型大鼠总路程、平均速度,增加静止时间。结论:补肝、益肾药物联合使用对更年期模型大鼠行为变化及子宫和阴道重量/系数,较补肝药与益肾药单独使用效果好,从方药的角度部分诠释了"肝肾同源"理论。

Objective： To explore the mechanism of ＂ Liver and kidney sharing the same origin＂ according to the herbs. Methods： Rat models of menopause were established via the castration. Weight, uterine and vaginal weight/ coefficient, and behavior were observed after treating with tonifying liver drugs, benefiting kidney drugs and tonifying liver and nourishing kidney drugs. Result： Weight, uterine and vaginal weight/coefficient, and rest time were increased obviously, and the total distance and average speed were decreased significantly after treating with tonifying liver and nourishing kidney drugs. Conclusion： On improving behavior changes and uterine and vaginal weight/coefficient of menopausal rats, the curative effects of the combination of tonifying liver drugs and benefiting kidney drugs were better than drugs used alone, which gave the interpretation of ＂ Liver and kidney sharing the same origin ＂ theory from the point of view of prescriptions and herbs.