幽门螺杆菌、胃泌素与慢性胃炎的关系

The Relationship Between Helicobacter Pyloric and Serum Gastrin in Chronic Superficial Gastritis

目的 :对慢性浅表性胃炎 (CGS)患者行幽门螺杆菌 (HP)及空腹血清胃泌素 (SG)检测 ,对HP( +)组和HP( -)组SG作对比 ,抗HP治疗前后SG、病理组织学作比较 ,探讨两者与CSG的关系。方法 :患者先行空腹作SG测定 ,再作胃镜检查 ,取胃窦粘膜 3块 ,分别作快速尿素酶试验、Giemsa染色及病理组织学检查。HP( +)组抗HP治疗 ,1月后重复上述检查。结果 :HP( +)组SG明显高于HP( -)组 (P <0 .0 5 ) ,治疗后HP转阴组较非转阴组SG明显下降 (P <0 .0 5 ) ,胃粘膜中性粒细胞浸润明显减轻。结论 :HP是CSG的主要病因 ,其刺激胃泌素释放增多是导致胃粘膜炎症的重要机制。

Purpose: To study the fasting serum gastrin (SG) level in patient with chronic superficial gastritis (CSG), which was divided into helicobacter pylori (HP) positive group and helicobacter pylori negative group. Methods: Fifty cases of CSG was diagnosticated by gastroscopy and be taked rapid ureas test, giemsa staining pathological examination on the histological biopsy from antral mucosa to differential cases in HP(+) group or HP(-) group. Than to repeat the same tests in HP still positive cases after a month of antibiotic therapy. Results: The SG level in HP(+) group was higher than HP(-) group significantly (P<0.05). After antibiotic therapy the SG level of HP still positive group also higher than the group in which HP have had conversed to negative and pathological examination was showed that the neutrophil infiltration of antral mucosa be decreased significantly. Conclusion: The infection of HP is the main causative agent in most cases of CSG. It stimulates the G cell to increase SG releasing being the major etiologic mechanism of CSG.