幽门螺杆菌感染对胃粘膜上皮表达ICAM-1的影响

Effect of Helicobacter Pylori on ICAM-1 Expression of Gastric Mucosa Epithelium

目的 :观察HP感染对胃粘膜上皮ICAM 1的影响。方法 :采用免疫组化方法对 47例HP感染阳性和 41例HP感染阴性患者的胃粘膜上皮细胞膜ICAM 1表达进行研究。结果 :HP感染阳性者ICAM 1表达增高 ,且与HP感染阴性者比较有显著性差异 (P <0 .0 5 )。结论 :HP感染促进胃粘膜上皮ICAM 1表达升高。

Purpose: To study effect of helicobacter pylori (HP) on intercellular adhesion molecule (ICAM-1) expression of gastric mucosa epithelium. Methods: Expression of ICAM-1 were studied in 47 patients with positive HP infection and 41 with negative HP infection by immunohist ochemical method. Results: The expression of ICAM-1 were significantly higher in the patients with positive HP infection than in the patients with negative HP infection (P<0.05). Conclusion: HP infection may increase ICAM-1 expression on the epithelium of gastric mucosa.