结直肠癌患者肿瘤血管形成的临床病理意义初探

The Clinicopathologic Significance of Tumor Angiogenesis in Colorectal Carcinoma

目的 :探讨结直肠癌血管形成与其临床病理特征的关系。方法 :用免疫组化S P法 ,对 6 2例结直肠癌石蜡切片进行染色和微血管计数。结果 :伴淋巴结转移、远处转移及Duke’sB、C期结直肠癌组织中 ,微血管计数分别高于其相应无转移及Duke’sA期病人。结论 :结直肠癌肿瘤血管形成与其转移密切相关 ,微血管计数测定血管形成可作为预测结直肠癌转移潜能的标志。

Purpose: To investigate the correlation between the tumor angiogenesis and the clinicopathologic characteristics in colorectal carcinoma. Methods: Microvessel count (MVC) in paraffin-embedded sections from 62 patients with primary colorectal carcinoma were measured by S-P method. Results: MVC in the patients with lymph node metastasis, distant metastasis,and Duke's B and C were significantly higher than those in the patients without metastasis and with Duke's A. Conclusion: There are close correlation between tumor angiogenesis and metastasis in colorectal carcinoma, angiogenesis expressed as MVC might be an indicator for predicting the metastasis potential of colorectal carcinoma.