左旋多巴联合综合疗法治疗青少年屈光不正性弱视的疗效观察

Efficacy of levodopa combined comprehensive treatment on the youth of ametropic amblyopia

目的比较左旋多巴联合综合法与单纯综合法治疗青少年屈光不正性弱视的疗效。方法对12岁以上76例(137只眼)屈光不正性弱视儿童随机分成2组,对照组采用综合治疗,实验组加服左旋多巴。治疗6个月,对视力、图形视觉诱发电位(P-VEP)、对比敏感度、融合范围、远近立体视等结果进行分析。结果实验组有效率为81.82%,对照组有效率为56.34%,两组有效率的比较有显著性差异(P<0.05)。实验组P-VEP中P100波的振幅和潜伏期与对照组比较有显著性差异(P<0.05)。实验组较对照组对比敏感度高,差异有显著性(P<0.05)。实验组矫正融合范围、矫正远近立体视功能的改善较对照组有显著差异(P<0.05)。结论对于青少年屈光不正性弱视患者,左旋多巴联合综合法治疗效果较好。对于青少年弱视患者不应该放弃治疗。

Objective Amblyopia is common disease in children. The treatment on the youth of amblyopia was also a focus and difficulty of past study. Present study is to investigate the efficacy of levedopa combined comprehensive treat- ment on the youth of ametropic amblyopia by comparing with isolated comprehensive therapy. Methods Totally 137 eyes of 76 cases of ametropic amblyopic children aged over 12 were divided into two groups randomly. The control group had com- prebensive treatment. Besides the comprehensive treatment, the experimental group had been treated by levedopa for 6 months. After 6 months of treatment, visual acuity, pattern-visual evoked potential（P-VEP） ,contrast sensitivity, fusion, near stereoacuity and distance stereoacuity were tested and analyzed. Results The effective rates of amblyopia in experi- mental group and control group were 81.82% ,56. 34% respectively. There was a significant difference in the effect rate between experimental group and control group （ P 〈 0.05 ）. Also the latency and ampitude of P100 of P-VEP of amblyopia were a significant difference in the effect rate between experimental group and control group （ P 〈 0.05 ）. The experimental group was better than the control group on the improvement of contrast sensitivity, fusion , near and distance stereoacuity （ P 〈 0.05 ）. Conclusion Levodopa was an effective method to improve visual fuction of youth amblyopia. United compre- hensive treament as better than the comprehensive treatment. Don＇ t give up treat the youth of Ametropic Amblyoia.