摘要
目的探讨尿视黄醇结合蛋白测定在汽油作业肾损害研究中的应用。方法选择１６０名职业接触者和８０名非职业接触者进行尿视黄醇结合蛋白（ ＲＢＰ）、尿β－乙酰氨基葡萄糖苷酶（ ＮＡＧ）、尿 β２－微球蛋白（β２－ＭＧ）的测定。结果检测结果显示职业接触组的ＲＢＰ、ＮＡＧ和β２－ＭＧ值均显著高于非职业接触组。异常率分析结果显示 ＲＢＰ异常率略低于 ＮＡＧ，但明显高于 β２－ＭＧ。结论 ＲＢＰ可优先 β２－ＭＧ作为慢性汽油肾损害的早期监测指标。
Objective Study the possibility of measurement of RBP in urine as an indicator of renal injury caused by gasoline exposure. Methods The retinal binding protein(RBP), N-acetyl-β -D-glucosaminidase(NAG) and β 2-microglobulin (β2 -MG) were measured in 160 peoples of occupational gasoline exposure and 80 peoples unexposed. Results The results show that the mean urinary level of RBP, NAG, β 2-MG in exposed group were significantly higher than unexposed group. The analysis of their positive rate show that the RBP positive rate is lower than NAG, but significantly higher than β2-MG. Conclusion RBP in urine is a more effective indicator of renal injury caused by gasoline exposure than β2-MG.
出处
《职业卫生与应急救援》
2000年第3期125-127,共3页
Occupational Health and Emergency Rescue
