膀胱癌术后射频热化疗对机体IL-2及TNF含量的影响

The influence of the radiofrequency thermochemotherapy on the content of interleukin 2 and tumor necrosis factor after bladder cancer resection

目的 :探讨术后热化疗对膀胱癌患者外周血interleukin 2 (IL 2 )、tumornecrosisfactor(TNF)含量的影响。方法 :5 8例膀胱移行细胞癌患者术后被随机分为热化疗组和化疗组。分别于治疗前及治疗后 2周检测两组患者外周血IL 2、TNF含量。 3 0例健康体检者作为正常对照。结果 :治疗前 ,两组患者血中IL 2含量明显低于对照组 ,TNF含量与对照组比较差异无显著性。热化疗后 2周 ,血中IL 2及TNF含量明显升高 ,与热化疗前比较差异具有显著性。结论 :术后射频热化疗可以提高膀胱癌患者血中IL 2、TNF含量 ,对抑制肿瘤的生长和复发具有重要意义。

Objective: To investigate the effects of radiofrequency thermochemotherapy (TCT)on the content of interleukin 2(IL 2)and tumor necrosis factor(TNF)after bladder cancer resection.Methods: 58 cases of transitional bladder cancer were randomly assigned to receive TCT(group A)and chemotherapy along(group B).After one week of surgery,the thermo-chemotherapy was managed.The serum content of IL 2 and TNF were test with radioimmunoassay before management and two weeks after that.30 normal adults were as controls(group C).Results: The serum content of IL 2 in group A and group B was obviously decreased than that in group C before management.The serum content of TNF in group A and group B had no significantly difference as compared to that in group C before management.The serum content of IL 2 and TNF was significantly increased after two weeks of TCT as compared to that before TCT.Conclusion: TCT has a benefite effect to increase the serum content of IL 2 and TNF.It would be a important way to prevent bladder cancer recurrence.