年龄因素对^90锶-^90钇敷贴器治疗皮肤血管瘤疗效的影响

Influence of age factor on treating cutaneous hemangioma with ^90Sr-^90Y applicator

目的探讨年龄因素对^90锶-^90钇（^90Sr-^90Y）敷贴器治疗皮肤血管瘤疗效的影响。方法对224例不同年龄段婴幼儿和儿童皮肤血管瘤患者进行^90Sr-^90Y敷贴器治疗，回顾性分析了其疗效与患者年龄的关系。结果（1）在1个月至〈1岁组和1至〈5岁组之间，1个月至〈1岁组和5～10岁组之间，1至〈5岁组和5～10岁组之间，其疗效差异均有统计学意义（P〈0．05）；随着患者年龄的增长，其痊愈率逐渐降低，而其显效率、好转率和无效率却逐渐升高。（2）^90Sr-^90Y敷贴器治疗后痊愈或显效的199例患者中，在1个月至〈1岁组和1至〈5岁组之间，1个月至〈1岁组和5～10岁组之间．其疗程分布差异均有统计学意义（P〈0．05）；在1至〈5岁组和5～10岁组之间，其疗程分布差异无统计学意义（P〉0．05）。随着患者年龄的增长，其所需疗程数呈增加的趋势。结论患者的年龄是影响^90Sr-^90Y敷贴器治疗皮肤血管瘤疗效的因素，患者年龄越小则疗效越好、疗程越短、射线的不良反应越轻。

Objective To explore the influence of age factor on the treatment of cutaneous hemangioma with （^90Sr-^90Y） applicator. Methods A total of 224 babies and children of different ages with cutaneous hemangioma were treated by using ^90Sr-^90Yapplicator. Then, the relation between their therapeutic effects and ages were analyzed respectively. Results The differences in the therapeutic effect between group of one month to less than one year and group of one to less than five years, and group of one month to less than one year and group of five to ten years, and between group of one to tess than five ages and group of five to ten years （P〈0. 05）, were statistically significant. With an increase of the age, the recovery rate gradually decreased, but their effective rate, improvement rate and ineffective rate increased. In the 199 well-healed or effective patients, the differences in the distribution of treatment course between group of one month to less than one year and group of one to less than five years, and group of one month to less than one year and group of five to ten years, were statistically significant （P（0.05）; but the difference in the distribution of treatment course between group of one to less than five ages and group of five to ten years was not statistically significant （P〉 0.05）. The number of treatment course presented an increased tendency with an increase of the age for patients. Conclusions The age of patients is a factor influencing the therapeutic effect on cutaneous hemangioma with ^90Sr-^90Y applicator. The younger the patients, the better their therapeutic effects, the shorter their courses of treatment, and the smaller the adverse reaction of beta ray.