淋巴细胞免疫治疗在反复种植失败和复发性自然流产中的作用

Role of lymphocyte immunotherapy in recurrent implantation failure and recurrent spontaneous abortions

现代免疫学观点认为,正常妊娠时母一胎界面表现为一种特殊类型的外周免疫耐受机制,这种耐受状态形成复杂,各种免疫因素通过有机协调形成网络,达到母胎间免疫平衡,使妊娠得以维持。成功的妊娠本身就是一个免疫矛盾所在。一方面胎儿抗原不能作为"半同种移植物"被母体识别,另一方面为了在母体中生存,胎儿抗原又必须呈递给母体,被母体接受。因此。

The immunization therapy with allogeneic lymphocytes （lymphocyte immunotherapy, LIT）has been introduced for the treatment of infertile women with recurrent spontaneous abortions（RSA） for more than 30 years. To date,LIT has been used in different centers worldwide,although the efficacy and mechanism are still debating. From a theoretical point of view, there are several common aetiologies for recurrent implantation failure（RIF）and RSA during IVF treatment. Subsets of natural killer cells（NK）and T helper lymphocytes in peripheral blood have been reported to be associated with RIF and RSA. The hypothesis that RIF and RSA have partly identical aetiologies has been acknowledged, which leads to various immunotherapeutic interventions such as LIT to be tested.