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正五聚蛋白3在炎症及自身免疫中的作用 被引量：14

Role of pentraxin 3 in inflammation and autoimmunity
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摘要 正五聚蛋白3（pentraxin 3,PTX3）属正五聚蛋白家族成员,又称肿瘤坏死因子刺激基因14（tumornecrosis factor-stimulated gene 14,TSG14）,是一种典型的急性期蛋白。PTX3作为唯一的可溶性模式识别受体,可以结合多种可溶性受体配体,参与免疫防御、炎症、细胞凋亡、血管重塑。 As a soluble pattern-recognition receptor, pentraxin 3 （PTX3） evolves in various physiological and pathological effects on inflammation, autoimmunity, apoptosis, vessel remodeling, female fertility and vascular endothelial injury. PTX3 is also a sensitive biological marker for detecting severity and activity of various autoimmune diseases. In most cases, PTX3 limits the progress of autoimmunity and plays a protective role in the process of autoimmune diseases.
作者 谢京 张静波
机构地区 第三军医大学附属新桥医院肾内科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2013年第4期752-756,共5页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目(No.30971366) 重庆市国际合作项目(No.CSTC201110004) 第三军医大学临床科研基金资助项目(No.2011XLC37)
关键词 急性期蛋白 正五聚蛋白3 天然免疫 炎症 自身免疫 Acute-phase reactive proteins Pentraxin 3 Innate immunity Inflammation Autoimmunity
分类号 R363 [医药卫生—病理学]
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共引文献40

同被引文献153

  • 1杨世伟,王大为,秦玉明,李军,王凤鸣,左维嵩.基质金属蛋白酶-9在川崎病外周血表达及其在冠状动脉损伤中的临床意义[J].南京医科大学学报（自然科学版）,2005,25(2):87-90. 被引量：5
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引证文献14

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中国病理生理杂志
2013年 第4期

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