摘要
N-Myc癌基因在胚胎期造血细胞增殖、分化过程中起着重要作用。一旦机体发生血液恶性肿瘤时,其表达量可升高,并与不良预后显著相关。本文就N-Myc的结构,对各系造血细胞的调控机制,参与各信号通路的交互作用,国内、外的过表达造模研究、药物干预等方面的研究进展作一综述。
N-Myc oncogene plays an important role in the process of hematopoietic cell proliferation and differentia- tion in embryos. Once the body suffers from hematologic malignancies, the expression of N-Myc would increase and sig- nificantly associate with disease progression. In this artical the structure of N-Myc, the regulatory mechanism in the dif- ferent hematopoietic lineages, the interaction in each signal pathways, the transgenic animal model of overexpression, and intervention by drugs are reviewed.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2013年第2期503-507,共5页
Journal of Experimental Hematology
基金
国家自然科学基金青年科学基金项目(编号30900636)
上海市科委基础研究重点项目(编号08JC1414900)
上海交通大学医学院科学基金(编号09XJ21066)
关键词
N-MYC
癌基因
造血系统
血液肿瘤
N-Myc
oncogene
hematopoietic system
hematologic malignancy