N-Myc在造血和血液肿瘤中的作用机制研究进展

Research Progress of N-Myc Roles in Hematopoiesis and Hematologic Malignancies——Review

N-Myc癌基因在胚胎期造血细胞增殖、分化过程中起着重要作用。一旦机体发生血液恶性肿瘤时,其表达量可升高,并与不良预后显著相关。本文就N-Myc的结构,对各系造血细胞的调控机制,参与各信号通路的交互作用,国内、外的过表达造模研究、药物干预等方面的研究进展作一综述。

N-Myc oncogene plays an important role in the process of hematopoietic cell proliferation and differentia- tion in embryos. Once the body suffers from hematologic malignancies, the expression of N-Myc would increase and sig- nificantly associate with disease progression. In this artical the structure of N-Myc, the regulatory mechanism in the dif- ferent hematopoietic lineages, the interaction in each signal pathways, the transgenic animal model of overexpression, and intervention by drugs are reviewed.