米索前列醇预防产后出血的临床观察

Clinical Observation on Prevention of Postpartum Bleeding by Misprostol

为观察米索前列醇用于预防产后出血的效果。选择有产后出血高危因素的产妇193例,随机分为米索前列醇组、米索前列醇+催产素组及催产素组。米索前列醇组65例,于胎儿娩出后立即口服米索前列醇600bμg、米索前列醇+催产素组62例,米索前列醇口服剂量与方法同米索前列醇组,于胎儿娩出后宫体肌肉注射催产素20IU。催产素组66例,胎儿娩出后宫体肌肉注射催产素20IU,再静脉滴注催产素20IU。以上各组观察产后2小时内出血量。结果产后2小时平均出血量,米索组为158±60.0mL;米索前列醇+催产素组为154±55.7mL;催产素组为284±95.4。米索前列醇组与催产素组比较,差异有极显著性(P<0.01)。米索前列醇组与米索前列醇+催产素组进行比较差异无显著性(P>0.05)。结果提示,米索前列醇促进子宫收缩作用强于催产素,能较好地预防产后出血,且用药方便安全。

To observe the effects of misprostol on prevention of postpartum hemorrhage. 193 cases of patients were divided into three groups at random: misprostol group (group A) , misprostol combined with oxytocin group (group B) ,oxytocin group(group C). Both 65 cases of group A and 62 cases of group B were administrated misprostol 600f orally at once after the delivery of fetus. 66 cases of group C were given 20IU oxytocin intravenously after the delivery of fetus. The amount of bleeding within 2 hours after delivery was measured. The mean amount of bleeding in group A was 158±60. 0ml, in group B with 154±55. 7ml, in group C with 284 + 95. 4ml. The diference in the amount of bleeding between group A and group C was of statistically significant( P <0. 01). There was no significanct diference between group A and group B( P >0. 05). Misprostol is more effective than oxytocin in controlling postpartum hemorrhage. This method is convenient and safty.