七叶皂苷钠治疗输尿管下段结石体外冲击波碎石(ESWL)术后的疗效观察

Sodium Aescinate for Injection for the Treatment of Lower Ureteral Calculi After Extracorporeal Shock Wave Lithotripsy

目的:探讨七叶皂苷钠对输尿管下段结石体外冲击波碎石术结石排出和疼痛缓解的疗效。方法:200例输尿管下段结石患者随机分为2组,每组100例,结石直径0.5～1.0 cm.。对照组仅采用ESWL,七叶皂苷钠组除采用ESWL外,给予七叶皂苷钠10 mg静点,每例患者均观察2周。结果:2周内结石排出率对照组为72%,七叶皂苷钠组为87%。两组比较差异有统计学意义(P<0.05)。七叶皂苷钠组发热、血尿、肾绞痛等并发症的发生率明显低于对照组,ESWL术后疼痛VAS评分七叶皂苷钠组明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:在输尿管下段结石体外冲击波碎石术后应用七叶皂苷钠在辅助排石方面是安全有效的,能够提高结石排出率,缩短结石排出时间,缓解疼痛,降低并发症发生率。

Objective： To evaluate the efficiency of sodium aescinate for injection for the treatment of lower ureteral calculi after extracorporeal shock wave lithotripsy. Methods： 200 patients were randomly assigned to 2 groups （each group 100） with the calculi diameter range from 0.5 to 1.0 cm, the control group did not perform any antispasm treatment except for extracorporeal shock wave lithotripsy. The sodium aescinate group was intravenous input 10 mg per day. The observation duration did not exceed 2 weeks. Results： The successful stone expulsion rate within 2 weeks were 72% and 87% in the control group and sodium aescinate group. The incidence of complications of the sodium aescinate group was shorter than the control group. And the visual analogue scale of the sodium aescinate group was also shorter than the control group. Statistical differences were significant between the two groups. Conclusion： tt is demonstrated the sodium aescinate is safe and effective for the treatment of lower ureteral calculi after extracorporeal shock wave lithotripsy. It can significantly improve the stone expulsion rate, relief the pain and reduce the incidence of complications.