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核糖核酸酶Ⅲ超家族与RNA干扰

RNaseⅢ superfamily and RNA interference
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摘要 核糖核酸酶Ⅲ(RNaseⅢ)是一个在生物体中普遍存在的酶类,它具有把RNA前体加工成有功能的RNA、参与RNA干扰和其它细胞活性的功能。RNaseⅢ超家族包括大肠杆菌的核糖核酸酶Ⅲ(RNaseⅢ)、酵母核糖核酸酶t1(Rnt1)、植物中的核糖核酸酶Dicer和哺乳动物中的核糖核酸酶Drosha,它们都具有在特定位点或者特定的序列区域识别和切割双链核糖核酸(dsRNA)的能力。对RNaseⅢ超家族的种类、结构和功能、作用机制及其在RNA干扰中所起的重要作用以及在生命科学研究中的应用进行了归纳总结。 RibonucleaselU （RNase Ⅲ ） is a ubiquitous enzyme in organisms. It can participate in transforming RNA precursor into functional RNA, get involved in RNA interference, and take part in the other cells＇ activities. RNaseⅢsuperfamily includes RNase Ⅲ in E. coli, Rntl in yeast, Dicer in plants, and Drosha in mammals. They all have the ability to recognize and cleave dsRNA at the specific sites or specific sequence regions. This paper reviews the types, structure and function, mechanism of RNase Ⅲ superfamily, and its important role in RNA interference.
作者 尹国华 莫国艳 赵国柱 朱常香 温孚江
机构地区 山东农业大学植物保护学院 山东农业大学作物学国家重点实验室 湖北中医药大学中药资源与中药复方教育部重点实验室 北京林业大学生物科学与技术学院 山东农业大学生命科学学院
出处 《北京联合大学学报》 CAS 2013年第2期49-54,共6页 Journal of Beijing Union University
关键词 RNaseⅢ超家族 RNA干扰 结构和功能 RNase Ⅲ superfamily RNA interference Structure and function
分类号 Q522 [生物学—生物化学]
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参考文献48

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北京联合大学学报
2013年 第2期

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