2009-2011年住院患者临床分离肠球菌耐药性分析

Surveillance of antimicrobial resistance in Enterococcus isolating from inpatients during 2009 and 2011

目的:分析2009-2011年我院临床分离肠球菌的耐药特点及流行分布,为合理治疗肠球菌感染提供依据。方法:收集我院住院及门诊患者连续分离的、不重复的肠球菌92株,以2010CLSI纸片扩散法为判断标准,对分离菌进行耐药性分析。结果:3年来从各种临床标本中共分离到粪肠球菌52株,屎肠球菌23株。标本主要来源于尿液(41%)和腹腔引流液(24%)。屎肠球菌对青霉素类、氟喹诺酮类、大环内酯类和高水平庆大霉素的耐药性均高于粪肠球菌;未检出耐万古霉素和利奈唑胺的肠球菌。结论:屎肠球菌的耐药性高于粪肠球菌,应加强对屎肠球菌的耐药监测,防止多重耐药菌的发生和传播。

Objective：To investigate the distribution and antimicrobial resistance in enterococcus from our hospital, and provide a basis for rational treatment of enterococcal infections. Methods ： A total of 92 non - duplicate nosocomial enterococcus was collected from inpatients. The antimicrobial susceptibility test was carried out by Kirby - Bauer method , then to analyze the data. Results： During the past 3 years, 52 strains of Enterococcus faecalis and 23 strains of Enterococcus faecium were isolates from a variety of clinical specimens. The majiority of strains were isolated from urine（41% ） and Abodominal fluid （24%）. The antimicrobial resistance of Enterococcus faecium showed higer to Penicillins,Fluoroquinolones,Macrolides and Aminoglycosides than Enterococcus faecalis; Van- comycin - resistant and Linezolid - resistant Enterococcus were not found. Conclusions： The antimicrobial resistance of Enterococcus faecium showed higer than Enterococcus faecalis,It is essential to strengthen the isolates measures in order to minimize further emer- gence and dissemination of antimicrobial resistance.