各种肝病患者血清TGFα含量与肝细胞损害的关系研究

Study on the Relationship between Liver Cell Damage and Transforming Growth Factor alpha Level in Different Type of Liver Diseases.

目的 :探讨转化生长因子α(Transforminggrowthfactor aplha ,TGFα)在各种肝病患者中的变化规律及其与肝细胞损害的关系。方法 :采用非平衡竞争性放射免疫法测定 172例各种肝病患者血清中TGFα含量。结果 :慢性中度肝炎、急性黄疸肝炎、慢性重度肝炎、肝硬化失代偿期、原发性肝癌患者血清TGFα含量分别为 12 .12± 7.35pg ml、14.19± 7.30 pg ml、15 74±9 6 5pg ml、16 .0 2± 9.18pg ml、19.89± 9.0 9pg ml,逐渐升高 ,明显高于对照组 6 .86± 0 .89pg ml(P <0 .0 5)。肝硬化失代偿期与代偿期组间差异有显著性 (P <0 .0 5)。结论 :血清TGFα含量明显升高对原发性肝癌的诊断有帮助。TGFα与各种肝病肝细胞的再生、分化、增殖以及损害有一定的关系。

Objective: To study the relationship between the level of transforming growth factor alpha(TGFα) and liver cell damage in different type of liver diseases. Methods: RIA method was used to detect the TGFα in sera from 172 patients.Result: The serum TGFα level in patients of chronic moderate hepatitis,acute hepatitis,chronic severe hepatitis,decompensation phase of liver cirrhosis,and hepatocellular carcinoma were 12.12±7.35pg/ml,14.19±7.30pg/ml,15.74±9 65pg/ml,16.02±9.18pg/ml and 19.89±9.09pg/ml,respectively,which were significantly higher than that of the control group (6.68±0.89pg/ml,P<0.05). There was a significant difference between the TGFα levels in the decompensation phase of liver cirrhosis and that of compensation phase(P<0.05). Conclusion: The detection of serum TGFα is useful for the diagnosis of hepatocellular carcinoma. There is a relationship between the TGFα level and liver cell damage.