纳洛酮治疗小儿重症肺炎合并心力衰竭的疗效

Clinical Effect of Naloxone Treatment to Severe Pneumonia Complicated With Heart Failure in Children

目的探讨纳洛酮在小儿重症肺炎合并心力衰竭中的临床治疗作用。方法选择2010年10月至2011年10月于本院就诊的65例重症肺炎合并心力衰竭患儿为研究对象,按照随机数字表法将其分为观察组(n=32)和对照组(n=33)。两组均接受基础治疗,观察组同时加用纳洛酮治疗。观察两组患儿症状、阳性体征缓解时间和治疗有效率(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与之签署临床研究知情同意书)。两组患儿年龄、性别、体温、临床症状、辅助检查结果等方面比较,差异无统计学意义(P>0.05)。结果两组患儿症状、阳性体征缓解时间比较,差异有统计学意义(P<0.05)。两组患儿治疗5d时治疗有效率比较,差异有统计学意义(P<0.05)。结论纳洛酮可有效缩短小儿重症肺炎合并心力衰竭的病程,临床治疗效果显著。

Objective To explore the clinical effect of naloxone to severe pneumonia complicated with heart failure in children. Methods From October 2010 to October 2011,65 children with severe pneumonia complicated with heart failure were included in the study,and randomly divided into observation group（n= 32） and control group（n= 33）. Basic treatment were given in both groups, and naloxone was given in observation group for treatment too. The symptoms and positive signs recovery time and effective rate were observed. There was no significant difference between two groups in age, sex, symptoms, lab results （P〉 0.05）. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First People＇s Hospital of Shangqiu. Informed consent was obtained from each parents. Results There had significant differences in symptoms and positive signs recovery time between two groups（P〈0.05）. There also had significant difference in effective rate between two groups（P〈0.05）. Conclusions Naloxone has a significant clinical effect to severe pneumonia complicated with heart failure in children, and it can effectively shorten the course of the disease.