丙泊酚通过保护线粒体结构和功能实现脑保护作用的研究现状

Research of the cerebral protective effects of propofol achieved by protecting mitochondrial structure and function

国内外的多项研究均已证实了丙泊酚对脑缺血一再灌注损伤具有保护作用，其脑保护作用极其复杂，是多途径、多位点交互作用的结果。还有许多研究证实，线粒体在脑缺血-再灌注损伤中起重要作用。本文从线粒体的结构，主要是从线粒体内、外膜上的不同通道[电压依赖性阴离子通道（VDAC）]、Ca^2＋单向转运通道、线粒体膜通道转换孔（MPTP）、外向延迟整流钾电流（Ik）及ATP敏感性K^＋通道（KATP）来探讨并总结丙泊酚抗缺血-再灌注损伤的可能机制。另外，线粒体上的各种酶（Na^＋，K^＋-ATP酶、Ca^2＋-ATP酶及细胞色素C）是线粒体实现细胞能量代谢的必要成分，直接影响其线粒体功能。因此，本文通过线粒体结构和功能这两方面对丙泊酚的脑保护作用进行综述。

A number of studies have confirmed the propofol has protective effects on cerebral ischemia - reperfusion injury at home and abroad, the cerebral protective effect is extremely complex that is the result of the many ways and many sites interaction. Many studies confirmed that mitochondria plays an important role in cerebral ischemia reperfusion injury, mainly from different channels of the inner and outer mitochondrial membrane （VDAC,Ca^2＋uniporter channel, MPTP, IK, KATP）to explore and summarize the possible mechanism of propofol resist ischemia -reperfusion injury. In addition, various enzymes（Na^＋, K^＋ -ATP enzyme, Ca^2＋ -ATP enzyme, cytochrome C） in the mitochondria is mitochondrial necessary component of cellular energy metabolism, directly affect the mitochondrial function. This article summarized that the mitochondrial structure and function of the cerebral protective effects of propofol by these two aspects.