摘要
目的研究硝酸异康唑新的合成工艺。方法以三氯苯乙酮为起始原料经过还原、N-烷基化,成醚和精制四步合成硝酸异康唑。结果总收率达到47.1%。结论该反应原料易得,反应简单可行,该工艺为硝酸异康唑的工业化生产提供了依据。
OBJECTIVE To study the new synthesis technology of isocinazole. METHODS The new technology is begin with 2,2＇,4＇-trichloroacetophenone and after reduction, N-alkylation, etherification and crystallization four-step to synthesis isoconazole. RESULTS The total yield of the reaction reached 47.1%. CONCLUTION The raw materials are easy to obtain and the reactions are simple. This technology provides the rule for industrialization and makes a contribution for the antifungal medicine industry.
出处
《中国现代应用药学》
CAS
CSCD
2013年第4期376-378,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
硝酸异康唑
新工艺
三氯苯乙酮
isocanozole
synthesis
2,2＇,4＇-trichloroacetophenone
