以卟啉类衍生物为光敏剂的光动力疗法的靶点研究进展

Studies on the Target of Photodynamic Therapy with Porphyrin Derivatives as Photosensitizer

目的介绍以卟啉类衍生物为光敏剂的光动力学疗法(PDT)的靶点研究进展。方法从光敏剂的分布特性、活性氧的产生与作用、PDT中细胞凋亡的线粒体途径方面阐明线粒体为卟啉类衍生物光动力反应的主要靶点。结论卟啉类衍生物作为最常用的光敏剂,能选择性浓集于靶部位产生活性氧,从而导致靶细胞的破坏。目前越来越多报道表明,在PDT中线粒体可能是最主要的靶点。

OBJECTIVE Introduce the studies progress on the target of photodynamic therapy （PDT） with porphyrin derivatives as photosensitizers. METHODS This article discussed the evidences of mitochondria as the target site in PDT with three lines of data： the distribution characters of porphyrin derivatives as the photosensitizers in the cell; reactive oxygen species, the mitochondrial pathway for cell apoptosis in PDT. RESULTS Porphyrin derivatives as the most common photosensitizers could selectively concentrated at the target cell to produce reactive oxygen species, which lead to the destruction of target cells. CONCLUSION About where is the PDT target site in the cell, there is no concensus in the early studies, but increasing studies found that mitochondria may be the main target in PDT.