托吡酯的合成研究进展

Progress in Synthesis of Topiramate

目的介绍托吡酯的研究背景和合成研究进展。方法综合国内外报道的文献,阐述托吡酯的合成方法。结果重点列出了关键中间体的合成方法以及酯化法、氨解法、催化氢化法和水解法4种托吡酯的合成方法,分析各方法特点。结论氨解法是托吡酯合成方法的主要研究方向。

OBJECTIVE To introduce the background and current synthesis progress of topiramate. METHODS To review both domestic and international published reports regarding the synthesis of topiramate. RESULTS Made a list of synthesis methods of a key intermediate and four synthesis methods of topiramate including esterification, ammonolysis, catalytic hydrogenation and hydrolyzation and analyzing characteristics of synthesis methods. CONCLUSION The method of ammonolysis provides us a main research direction for efficient synthesis topiramate.