乳腺癌的全数字化乳腺摄影与增强MRI应用ROC曲线对比研究

Comparative study of full-field digital mammography and contrast-enhanced MRI on diagnosis of breast cancer by ROC curve analysis

目的:对比性研究全数字化乳腺摄影(full-field digital mammography,FFDM)和磁共振(MRI)增强扫描在乳腺癌的诊断价值。方法:回顾性分析广西医科大学第一附属医院收治的160例乳腺肿物患者的资料,所有病例均接受FFDM、MRI增强检查和手术病理检查。应用Medcalc软件对影像资料进行ROC曲线分析,比较FFDM和增强MRI诊断乳腺癌的准确性。结果:160例患者中,FFDM检出肿块131例,发现钙化37例,同侧腋下淋巴结肿大23例;MRI增强扫描检出肿块134例,发现钙化31例,同侧腋下淋巴结肿大28例。ROC曲线分析FFDM和增强MRI曲线下面积(AUC)分别是0.924和0.929,P>0.05,在诊断乳腺癌的准确性上,两者差别无统计学意义。结论:FFDM是筛查乳腺癌的首选检查方法,增强MRI能更多地显示乳腺癌病灶的特征,两者结合应用可以提高乳腺癌的诊断正确率。

Objective To compare the value of full-field digital mammography （FFDM） and contrast- enhanced MRI on diagnosis of breast eaneer. Methods A retrospective study of 160 patients with breast lump treated in the First Affiliated Hospital of Guangxi Medical University were conducted. All cases were examined by FFDM, contrast-enhanced MRI and pathology. ROC curve analysis were used to compare their accuracy rate of diagnosis on breast cancer by Medcale soflwares. Results 131 patients with mass, 37 patients with calcification and 23 patients with ipsilateral axillary lymphadenopathy were detected by FFDM. 134 patients with mass, 31 patients with calcification and 28 patients with ipsilateral axillary lymphadenopathy were detected by contrast- enhanced MRI.AUC of FFDM is 0.924 and AUC of contrast-enhanced MRI is 0.929. P 〉 0.05 shows their difference wasn＇t considered statistically significant. Conclusion FFDM was the first choice of imaging examination for breast cancer. Contrast-enhanced MRI can clearly show characteristic of breast cancer. The combination of the two applications can improve the correct diagnosis rate for breast cancer.