某三级甲等传染病医院2007-2012年3、4月和10、11月氟喹诺酮类药应用情况分析

Analysis of the Utilization of Fluoroquinolones in a Third-grade Class-A Infectious Disease Hospital in Mar.,Apr.,Oct. and Dec. during 2007-2012

目的:评价某三级甲等传染病医院实施干预措施后氟喹诺酮类药的应用情况。方法:对该院2007-2012年每年3、4月和10、11月氟喹诺酮类药的用药频度(DDDs)、使用强度(AUD)等进行回顾性分析。结果:每年4个月中氟喹诺酮类药的DDDs从2007年的2132下降至2012年的615;AUD由2007年的4.64DDDs/100人/天下降至2012年的0.92DDDs/100人/天;住院患者使用该药的比例从2007年的14.85%下降至2012年的2.36%,降幅达84.10%。氟喹诺酮类药销售金额降幅达75.52%,日均费用由2007年的2.62元下降至2012年的0.44元,平均降幅达83.20%。以全院该类药消耗DDDs/100接诊人次和以全院该类药消耗DDDs/100住院日两种方式表示的全院氟喹诺酮类AUD显示有良好的相关性(r=0.99,P<0.05)。各年度10、11月该类药的DDDs、AUD均低于同年3、4月水平。结论:实施长期干预措施,结合医院有效的感染控制,氟喹诺酮类药用量呈逐步、稳定和明显减少的趋势。

OBJECTIVE： To evalue the utilization of fluoroquinolones in a third-grade class-A infectious disease hospital after the implementation of intervention measures. METHODS： The utilization of fluoroquinolones in the hospital in Mar., Apr., Oct. and Dec. during 2007--2012 were analyzed retrospectively in terms of DDDs and AUD. RESULTS： The DDDs of fluoroquinolones decreased from 2 132 in the 4 months of 2007 to 615 in those of 2012; and AUD fell to 0.92 DDDs/100 persons/day in 2012 from 4.64 DDDs/100 persons/day in 2007; the proportion of hospitalized patients administrated with fluoroquinolones decreased from 14.85% in 2007 to 2.36% in 2012, decreasing by 84.10%. The consumption sum of fluoroquinolones decreased by 75.52%, and DDC of that decreased from 2.62 yuan in 2007 to 0.44 yuan in 2012, decreasing by 83.20%. The AUD of whole hospital by DDDs/ 100 outpatient-services and by DDDs/100 hospitalization day showed good correlation with statistical significance （r=0.99, P〈 0.05）. The DDDs and AUD of fluoroquinolones in Oct. and Dec. were lower than in Mar. and Apr. of same year. CONCLUSIONS ： With the intervention measures, combined with effective hospital infection control, the reduction of fluoroquinolones consumption is progressive, stable and obvious.